Basal-like cancers and triple-negative cancers overlap with each other. Not all triple-negative breast cancers are basal-like, and not all basal cancers are triple-negative, though most triple-negative breast cancers are basal and most basal cancers are triple-negative. Since the definition of a basal cancer is a definition derived from the area of genomics, my suspicion here is that the pathologist was using basal and triple-negative in the overlapping sense rather than in a well-defined genetic sense. From a prognostic standpoint, if a tumor is basal or if it is triple-negative, that is a tumor that probably puts one at higher risk of recurrence in the absence of systemic therapy. But as we have mentioned earlier, these tumors are frequently very sensitive to systemic chemotherapy in terms of preventing recurrence and death. And as we mentioned, this is only one factor among many that determines prognosis; other factors being the stage and grade of the tumor.
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