How about the p53 gene? Seems that the triple-negative is also commonly associated with the overexpression of p53. What significance does this gene pl

p53 has been called the “guardian of the genome.” That is to say p53's role in normal cells is to tell a cell to in essence commit suicide if its DNA has been damaged. In many cancers, but particularly in triple-negative breast cancers, p53 may be mutated and may no longer be performing the purpose intended by nature. Unfortunately, while we can measure p53 in cancer cells and while it is clear that mutated p53 is a poor prognostic factor in many human cancers, there is little we can do therapeutically about this problem at present, although this is an active area of pre-clinical research.