If we look at hormone receptor status, women who are estrogen-receptor negative but progesterone-receptor positive represent a true minority and a small minority of breast cancer patients, probably representing less than 5% of all breast cancer patients. Many pathologists looking at this issue feel that estrogen-receptor negative/progesterone-receptor positive may represent an artifact of pathology, i.e., an error in testing. The error could be in two ways -- one could be that the tumor is estrogen-receptor positive and progesterone-receptor positive or the tumor could be truly estrogen-receptor negative and progesterone-receptor negative. So if there is any serious question then it is always reasonable to ask the pathologist to cut another slice from the block and retest. From a treatment standpoint, if a tumor is estrogen-receptor negative and progesterone-receptor positive, it is reasonable to consider hormonal therapy, though one suspects that the benefit for such patients would be less with hormonal therapy than in a patient who is strongly estrogen-receptor positive or progesterone-receptor positive.
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