Sunday, July 26, 2009

What causes this type of cancer? How is it normally treated? What is the cure rate? Will I have to take medication for the rest of my life?

The short answer is we don't know what causes inflammatory breast cancer. We do know that there seem to be differences in the frequency with which it is diagnosed in different parts of the world. In northern Africa and sub-Saharan Africa, they report much higher rates than in North America or Western Europe. I'm unsure if that is a real difference or not, but the true cause of inflammatory breast cancer to the best of my knowledge is not known. We have emerging information that suggests the molecular abnormalities that can be found in inflammatory breast cancer might be different in frequency when compared with non-inflammatory breast cancer. So for instance, reports suggest that the frequency of HER2 is more common in inflammatory breast cancer than in non-inflammatory breast cancer. There are reports to suggest that genes that predispose to blood vessel formation are more frequently activated in inflammatory breast cancer. Then there are several additional molecular differences, but that still doesn't give us a cause. But it might in the future give us a lead to develop treatments that are perhaps more specific for inflammatory breast cancer than what we use today.

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